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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are typically characterized by a focus on practical aspects of the study design, including the recruitment process and consent in adherence, as well as the use of routinely available equipment.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed a variety of investigators and had participants from different geographical regions. This kind of heterogeneity is necessary for practical trials to be valid and reduces the chance of bias in the results. However, too much heterogeneity can result in problems with the trial design.

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Pragmatic trials aim to mimic real-life situations and attain maximum external validity. They are usually commissioned by policymakers and practitioners in order to guide their decisions. They also provide a useful way to identify the causality between an intervention and its results. However, they shouldn't be used in lieu for explanatory trials.

The pragmatism idea is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials that inform the practice and policy decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool attempted to define the characteristics of a pragmatic research study which includes recruitment, 프라그마틱 체험 데모 (https://appc.cctvdgrw.com/home.php?mod=space&uid=1377486) design, implementation of the intervention, and follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the keywords naturalistic and pragmatic, limited to randomized controlled trials (RCTs) produced 34 articles, as shown in red in Figure 2. This is a sign that the health science community is becoming more sensitive to the subject of pragmatism. It is important to remember that the majority of these studies were conducted in primary-care settings.